1. 微流控单细胞操控与质谱分析；2. 手性分离与分析方法。

欢迎不同学科和专业背景、对本课题组研究方向及相关交叉研究感兴趣的同学加入课题组。研究方向包括微流控单细胞分析、手性分离分析等，具体事宜可通过电子邮件咨询。

围绕微流控单细胞分析与手性分离分析开展研究。面向单细胞化学信息的高时空分辨获取需求，构建了开放式微流控探头及微流控–质谱联用方法体系，实现了单细胞局部刺激、亚细胞成分取样、细胞膜损伤与修复行为表征以及行为–分子组成关联分析。同时，开展手性分离介质与分析方法研究。以第一作者或通讯作者身份在 Chem. Rev.、Chem. Soc. Rev.、Angew. Chem. Int. Ed.、Chem. Sci.、Anal. Chem. 等期刊发表论文15篇。主持国家自然科学基金青年科学基金项目（C类）和中国博士后科学基金面上资助项目各1项，获授权中国发明专利3项。

1. 国家自然科学基金青年科学基金项目（C类）（原青年科学基金项目），“同一单细胞行为及组分检测的微流控–质谱分析方法研究与应用”，2025—2027，主持，在研。

2. 中国博士后科学基金面上资助项目，“开放式微流控双水相流体聚焦用于原位亚细胞化学损伤及修复再生行为研究”，2022—2024，主持，结题。

[1] Qiang Zhang^#, Wenjun Liao^#, Ling Lin*, XiuJun James Li, Jiaxu Lin, Yang Song, Ying Hou, Jin-Ming Lin*. Methods toward Single-Cell Total-Analysis. Chem Rev, 2026, 126, 7068-7111.

[2] Yunan Wang, Qiang Zhang*, Yue Cheng*, Chenglong Shi, Yong Wang, Xiaofei Ma*. Liposome-Cyclodextrin Synergistic System for Enhanced Chiral Separation of Fmoc-Amino Acid Enantiomers in Capillary Electrophoresis. Microchim Acta, 2026, 193, 501.

[3] Yuhan Wang, Jinzheng Liu, Hao Xu, Shuo Yang*, Qiang Zhang*, Libing Zhang, Yin Xiao*. An Integrated Derivatization-LC-MS Strategy Reveals Cell-Type-Specific Chiral Amino Acid Profiles. J Chromatogr A, 2026, 1776, 466931.

[4] Jingjing Zhang, Defeng Qi*, Qiang Zhang*, Yin Xiao. Cyclodextrin-mediated synthesis of PdM (M=Co, Ni) bimetallic ultrafine nanocatalyst for efficient oxygen reduction reaction. Int J Hydrog Energy, 2025, 144: 275-285.

[5] Yongze Xiao, Ruxi Zhang, Hongxu Li, Qiang Zhang*, Yin Xiao*. 1D-2D composite perovskite films with self-assembled chiral structure for non-reciprocal circularly polarized emission modulation. Chem Commun, 2025, 61(42): 7668-7671.

[6] Chenglin Zhang, Xiangyun Yu, Yin Xiao*, Qiang Zhang*. Teicoplanin-cyclodextrin bilayer chiral stationary phase boosts chiral separation of native amino acids. Analyst, 2025, 150(10): 2146-2152.

[7] Chenglin Zhang^#, Yanqi Du^#, Ye Lu, Leyi Wang, Dequan Wang, Qiang Zhang*, Yong Wang, Yin Xiao*. β-Cyclodextrin modified imidazole probe specific recognition of organic acids based on nuclear magnetic resonance. Analyst, 2025, 150, 272-280.

[8] Qiang Zhang, Ling Lin*, Xizhen Yi, Tianze Xie, Gaowa Xing, Yuxuan Li, Xiaorui Wang, Jin-Ming Lin*. Microfluidic Sampling of Undissolved Components from Subcellular Regions of Living Single Cells for Mass Spectrometry Analysis. Anal Chem, 2023, 95, 18082-18090.

[9] Qiang Zhang, Tianze Xie, Xizhen Yi, Gaowa Xing, Shuo Feng, Shulang Chen, Yuxuan Li, Jin-Ming Lin*. Microfluidic Aqueous Two-phase Focusing of Chemical Species for In-Situ Subcellular Stimulation. ACS Appl Mater Interfaces, 2023, 15, 45640-45650.

[10]Yang Song, Qiang Zhang*, Yuxuan Li, Jiaxu Lin, Jin-Ming Lin*. In Situ Time-controllable Chemical Plasma Membrane Injury by Microfluidic Probe Reveals Self-repair Ability of Single Cells. Adv Mater Technol, 2023, 8, 2301147.

[11]Qiang Zhang, Shuo Feng, Weiwei Li, Tianze Xie, Wanling Zhang, Jin‐Ming Lin*. In situ stable generation of reactive intermediates by open microfluidic probe for subcellular free radical attack and membrane labeling. Angew Chem Int Ed, 2021, 60, 8483-8487.

[12]Qiang Zhang, Shuo Feng, Ling Lin*, Sifeng Mao, Jin-Ming Lin*. Emerging open microfluidics for cell manipulation. Chem Soc Rev, 2021, 50, 5333-5348.

[13]Qiang Zhang^#, Sifeng Mao^#, Weiwei Li, Qiushi Huang, Shuo Feng, Zhanying Hong, Jin-Ming Lin*. Microfluidic adhesion analysis of single glioma cells for evaluating the effect of drugs. Sci China Chem, 2020, 63, 865-870.

[14]Qiang Zhang, Sifeng Mao, Mashooq Khan, Shuo Feng, Wanling Zhang, Weiwei Li, Jin-Ming Lin*. In situ partial treatment of single cells by laminar flow in the "open space". Anal Chem, 2019, 91, 1644-1650.

[15] Sifeng Mao^#, Qiang Zhang^#, Haifang Li, Wanling Zhang, Qiushi Huang, Mashooq Khan, Jin-Ming Lin*. Adhesion analysis of single circulating tumor cell on base layer of endothelial cells using open microfluidics. Chem Sci, 2018, 9, 7694-7699